Atrasentan Hydrochloride

Preferred Label : Atrasentan Hydrochloride;

NCIt synonyms : (2R,3R,4S)-4-(1,3-Benzodioxo-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic Acid Monohydrochloride; Atrasentan;

NCIt definition : The orally available hydrochloride salt of pyrrolidine-3-carboxylic acid with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.;

UNII : E4G31X93ZA;

InChIKey : IJFUJIFSUKPWCZ-SQMFDTLJSA-N;

CAS number : 195733-43-8;

Drug name : Xinlay;

Molecule name : ABT-627; ( )-A 127722;

Chemical formula : C29H38N2O6.ClH;

NSC code : 720763;

Details

Origin ID

C1779;

UMLS CUI

C1765313;

Currated CISMeF NLP mapping
- Atrasentan Hydrochloride [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Atrasentan [MeSH Descriptor]
- atrasentan [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Atrasentan [NCIt concept]
has_target
- Endothelin-1 Receptor [NCIt concept]
is_salt_form_of
- Atrasentan [NCIt concept]

Keyword's position in hierarchy(ies) :

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