Antigen Presentation Pathway

Preferred Label : Antigen Presentation Pathway;

NCIt related terms : Antigen Processing and Presentation;

Alternative definition : BIOCARTA: Invariant chain (Ii) associates with newly synthesized class II molecules in the endoplasmic reticulum (ER), an interaction that has been shown to interfere with peptide binding to class II molecules. The class II-associated invariant chain peptide (CLIP) region (residues 81-104) of Ii is believed to mediate this inhibition by engaging the binding domain of class II like an antigenic peptide. Together, these findings have given rise to a model in which CLIP association with the class II groove acts to prevent inappropriate presentation of peptides imported into the ER for association with major histocompatibility complex class I molecules. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_mhcPathway;

Details

Origin ID

C39153;

UMLS CUI

C1516014;

Automatic exact mappings (from CISMeF team)
- antigen processing and presentation [OBI concept]
- antigen processing and presentation [GO term]
Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Antigen Peptide Transporter 1 [NCIt concept]
- Antigen Peptide Transporter 2 [NCIt concept]
- HLA Class I Histocompatibility Antigen, A-2 Alpha Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen Gamma Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DR Alpha Chain [NCIt concept]
- Prostate-Specific Antigen [NCIt concept]
pathway_has_gene_element
- CD74 wt Allele [NCIt concept]
- HLA-A wt Allele [NCIt concept]
- HLA-B wt Allele [NCIt concept]
- HLA-C wt Allele [NCIt concept]
- HLA-DQB1 wt Allele [NCIt concept]
- HLA-DRA wt Allele [NCIt concept]
- KLK3 wt Allele [NCIt concept]
- TAP1 wt Allele [NCIt concept]
- TAP2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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