HLA Class II Histocompatibility Antigen Gamma Chain

Preferred Label : HLA Class II Histocompatibility Antigen Gamma Chain;

NCIt synonyms : CD74 Antigen; CD Antigen CD74; CD74; Ia Antigen-Associated Invariant Chain; Ii; p33; HLA-DR Antigens-Associated Invariant Chain;

NCIt definition : HLA class II histocompatibility antigen gamma chain (296 aa, 34 kDa) is encoded by the human CD74 gene. This protein plays a role in MHC class II-dependent immunity.;

Details

Origin ID

C97420;

UMLS CUI

C4082587;

Automatic exact mappings (from CISMeF team)
- Blood group, I system [OMIM Phenotype]
- Cd74 antigen [OMIM gene]
- Roman numeral II (qualifier value) [SNOMED CT concept]
- inhibitor of growth family member 1 [ORDO Gene]
- invariant chain [MeSH Supplementary Concept]
OMIM relation
- Cd74 antigen [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- CD74 Gene [NCIt concept]
- Immunoprotein Gene [NCIt concept]
- MHC Class II Gene [NCIt concept]
gene_product_expressed_in_tissue
- CD4-Positive T-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- HLA Complex [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- CD74 NP_001020329.1:p.P98S [NCIt concept]
- CD74 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Antigen Presentation Pathway [NCIt concept]
- Antigen Processing and Presentation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Presentation [NCIt concept]
- Humoral Immunity [NCIt concept]
- Immune System Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Signal Transduction Induction [NCIt concept]
is_target
- Anti-CD74 Antibody-drug Conjugate STRO-001 [NCIt concept]
- Milatuzumab [NCIt concept]
- Milatuzumab-Doxorubicin Antibody-Drug Conjugate IMMU-110 [NCIt concept]

Keyword's position in hierarchy(ies) :

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