Preferred Label : Milatuzumab;
NCIt synonyms : Humanized Anti-CD74 Monoclonal Antibody hLL1; Monoclonal Antibody hLL1;
NCIt related terms : hLL1;
NCIt definition : A humanized monoclonal antibody directed against human CD74 with potential antineoplastic
activity. Milatuzumab specifically binds to CD74 on CD74-positive cells. Although
the exact mechanism through which this agent induces apoptosis is unknown, it may
involve antibody-dependent cellular cytotoxicity (ADCC) or complement-mediated cytotoxicity
(CMC). Alternatively, as CD74 is the cellular receptor for the cytokine migration-inhibitory
factor (MIF), the cytotoxicity of this agent may be related to inhibition of CD74
activation by MIF. CD74, an integral membrane protein that functions as an MHC class
II chaperone, may also be an accessory-signaling molecule; activation of CD74 may
initiate cell survival mechanisms involving induction of a signaling cascade resulting
in NFkB activation, entry of stimulated cells into the S phase of the cell cycle,
elevation of DNA synthesis, cell division, and augmented expression of Bcl-xL.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of multiple myeloma and several
other types of cancer. It binds to CD74, a protein on the surface of myeloma cells
and certain other types of cells. It may help kill cancer cells. hLL1 is a type of
monoclonal antibody.;
UNII : 2OP4E0GC6V;
CAS number : 899796-83-9;
Molecule name : IMMU-115;
Codes from synonyms : CDR0000662011; CDR0000662010;
Origin ID : C66983;
UMLS CUI : C2716103;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
