Preferred Label : Anti-CD74 Antibody-drug Conjugate STRO-001;
NCIt synonyms : Anti-CD74 ADC STRO-001; ADC STRO-001; Anti-CD74 Antibody-drug Conjugate BN301;
NCIt related terms : BEZETABART DEBOTANSINE;
NCIt definition : An antibody-drug conjugate (ADC) comprised of an aglycosylated human anti-CD74 IgG1
antibody (SP7219) that has been genetically modified to incorporate the non-natural
amino acid (nnAA) para-azidomethyl-L-phenylalanine (pAMF), which is site-specifically
conjugated to a non-cleavable dibenzocyclooctyne (DBCO)-maytansinoid linker-warhead,
with potential antineoplastic activity. The antibody moiety of anti-CD74 ADC STRO-001
targets and binds to the CD74 expressed on tumor cells; upon internalization, the
maytansinoid linker-warhead moiety binds to tubulin and disrupts microtubule assembly/disassembly
dynamics, which results in the inhibition of both cell division and cell growth of
CD74-expressing tumor cells. CD74, a transmembrane glycoprotein and tumor-associated
antigen (TAA) involved in major histocompatibility complex (MHC) class II protein
formation and localization, is a receptor for macrophage migration inhibitory factor
(MIF; MMIF). MIF binding induces intramembrane cleavage of CD74, which liberates the
cytosolic intracellular domain (ICD) of CD74 and regulates the expression of genes
involved in promoting cell survival. CD74 is overexpressed on cells from hematologic
B-lineage malignancies.;
UNII : 0D8BWL78LD;
Molecule name : STRO-001; SP7675; BN-301; BN 301;
NCI Metathesaurus CUI : CL545806;
Origin ID : C148066;
UMLS CUI : C4688623;
Semantic type(s)
- concept_is_in_subset
- has_target
