NCIt definition : An immunoconjugate consisting of milatuzumab, a humanized monoclonal antibody against
CD74, conjugated to the anthracycline antibiotic doxorubicin with potential antineoplastic
activity. The milatuzumab moiety of this ADC selectively binds to CD74 on tumor cell
surfaces; upon internalization, the doxorubicin moiety is released, where it intercalates
between base pairs in the DNA helix and inhibits topoisomerase II, thereby preventing
DNA replication and increasing double-strand breakage. As a result, this agent may
inhibit the proliferation of cancer cells that overexpress CD74. CD74, an integral
membrane protein and tumor associated antigen (TAA), is overexpressed in certain cancer
cells and promotes survival in rapidly proliferating tumor cells.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of multiple myeloma and several
other types of cancer. It binds to CD74, a protein on the surface of myeloma cells
and certain other types of cells. It may help kill cancer cells. IMMU-110 is a type
of monoclonal antibody.;