Preferred Label : Adenosine Receptor A2a;
NCIt synonyms : RDC8; hA2aR; Adenosine A2 Receptor; Adenosine Receptor Subtype A2A; ADORA2A; Adenosine A2A Receptor; ADORA2; Adenosine-A2A Receptor;
NCIt definition : Adenosine receptor A2a (412 aa, 45 kDa) is encoded by the human ADORA2A gene. This
protein plays a role in G protein-coupled receptor signaling, phagocytosis, blood
circulation, inflammatory response, sensory perception and central nervous system
development;
NCIt note : Expressed in basal ganglia, vasculature, and platelets by human ADORA2A Gene (GPCR1
Family), 412-aa 45-kDa Adenosine A2A Receptor is a cell-surface integral membrane
protein containing 7 transmembrane domains that interacts with a heterotrimeric G
protein complex in response to adenosine ligand to stimulate cAMP accumulation through
adenylate cyclase activation, is a major target of caffeine, and modulates the activity
of various neuronal populations, platelets, neutrophils, and mast cells, and smooth
muscle cells in bronchi and vasculature. A potent biologic mediator, most effects
of adenosine protect cells during stress.;
Origin ID : C38612;
UMLS CUI : C1527412;
Currated CISMeF NLP mapping
- False automatic mappings
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
- is_target
