Preferred Label : Ciforadenant;
NCIt synonyms : Adenosine-A2A Receptor-Targeting Agent CPI-444; 3H-1,2,3-Triazolo(4,5-d)pyrimidin-5-amine, 7-(5-Methyl-2-furanyl)-3-((6-((((3S)-tetrahydro-3-furanyl)oxy)methyl)-2-pyridinyl)methyl)-;
NCIt definition : A small molecule immune checkpoint inhibitor of the adenosine A2A receptor (ADORA2A)
with potential antineoplastic activity. Upon oral administration, ciforadenant binds
to adenosine A2A receptors expressed on the surface of immune cells, including T-lymphocytes,
natural killer (NK) cells, macrophages and dendritic cells (DCs). This prevents tumor-released
adenosine from interacting with the A2A receptors on these key immune surveillance
cells, thereby abrogating adenosine-induced immunosuppression in the tumor microenvironment.
This may stimulate anti-tumor immune responses, resulting in tumor regression.;
UNII : 8KFO2187CP;
InChIKey : KURQKNMKCGYWRJ-HNNXBMFYSA-N;
CAS number : 1202402-40-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1202402-40-1
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G-SRS /a ;
Molecule name : V81444; CPI-444;
NCI Metathesaurus CUI : CL504345;
Origin ID : C125659;
UMLS CUI : C4724815;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
