Preferred Label : Adenosine A2A Receptor Antagonist JNJ-86974680;
NCIt synonyms : A2AR Antagonist JNJ-86974680;
NCIt definition : An immune checkpoint inhibitor and antagonist of the adenosine A2A receptor (A2AR;
ADORA2A), with potential immunomodulating and antineoplastic activities. Upon administration,
A2AR antagonist JNJ-86974680 selectively binds to and inhibits A2AR expressed on T-lymphocytes.
This prevents tumor-released adenosine from interacting with the A2A receptors, thereby
blocking the adenosine/A2AR-mediated inhibition of T-lymphocytes. This results in
the proliferation and activation of T-lymphocytes, and stimulates a T-cell-mediated
immune response against tumor cells. A2AR, a G protein-coupled receptor, is highly
expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits
their proliferation and activation. Adenosine is often overproduced by cancer cells
and plays a key role in immunosuppression.;
Molecule name : JNJ 86974680; JNJ-86974680;
NCI Metathesaurus CUI : CL1921772;
Origin ID : C202467;
UMLS CUI : C5907974;
Semantic type(s)
- concept_is_in_subset
- has_target
