Preferred Label : Taminadenant;
NCIt synonyms : A2AR Antagonist PBF-509; 4-Pyrimidinamine, 5-Bromo-2,6-di-1H-pyrazol-1-yl-;
NCIt definition : An orally bioavailable adenosine A2A receptor (A2AR) antagonist, with potential antineoplastic
activity. Upon administration, A2AR antagonist PBF-509 selectively binds to and inhibits
A2AR expressed on T-lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition
of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells,
thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled
receptor, is highly expressed on the cell surfaces of T-cells and, upon activation
by adenosine, inhibits their proliferation and activation. Adenosine is often produced
in excess by cancer cells.;
UNII : 84I5UEP321;
InChIKey : ATFXVNUWQOXRRU-UHFFFAOYSA-N;
CAS number : 1337962-47-6;
Molecule name : PBF-509;
Origin ID : C121664;
UMLS CUI : C5235379;
Semantic type(s)
- concept_is_in_subset
- has_target
