Preferred Label : tofacitinib;

Obsolete resource : false;

MeSH note : structure in first source;

CISMeF synonym : CP 690,550;

MeSH synonym : tasocitinib;

MeSH hyponym : CP690550; CP-690550; CP 690550; CP-690,550;

MeSH Related Number : tofacitinib citrate; O1FF4DIV0D;

Related CAS MeSH : O1FF4DIV0D (tofacitinib citrate);

Chemical formula : C16H20N6O;

Is substance : O;

UNII : 87LA6FU830;

InChIKey : UJLAWZDWDVHWOW-YPMHNXCESA-N;

Details


Main resources

You can consult :


https://www.has-sante.fr/jcms/p_3486233/fr/xeljanz-tofacitinib-arthrite-juvenile-idiopathique-aji
2024
false
false
false
France
Product containing only tofacitinib in oral dose form (medicinal product form)
tablets
pharmaceutical solutions
administration, oral
treatment outcome
insurance, health, reimbursement
child
adolescent
Polyarticular juvenile idiopathic arthritis
tofacitinib
evaluation of the transparency committee
arthritis, juvenile
Polyarticular Juvenile Idiopathic Arthritis
tofacitinib

---
https://www.has-sante.fr/jcms/p_3403968/fr/xeljanz-tofacitinib-spondylarthrite-ankylosante
2023
false
false
false
France
treatment outcome
insurance, health, reimbursement
administration, oral
adult
tofacitinib
Janus Kinase Inhibitors
evaluation of the transparency committee
spondylitis, ankylosing
tofacitinib

---
https://ansm.sante.fr/tableau-marr/tofacitinib
2023
false
false
false
France
French
risk management
tofacitinib
tofacitinib
continuity of patient care
checklist
guidelines for drug use
patient education handout
Janus Kinase Inhibitors
tofacitinib
Drug-Related side effects and adverse reactions
Janus Kinase Inhibitors
pregnancy
teratogens
Virus Reactivation
tuberculosis
neoplasms
embolism and thrombosis
herpes zoster

---
Health Canada safety review finds link between the use of Xeljanz and Xeljanz XR (tofacitinib) and increased risk of serious heart-related issues and cancer
https://recalls-rappels.canada.ca/fr/avis-rappel/examen-innocuite-mene-sante-canada-revele-lien-entre-prise-tofacitinib-xeljanz-et
2022
false
false
false
Canada
French
English
risk
tofacitinib
pharmacovigilance note
tofacitinib
risk factors
arthritis, rheumatoid
colitis, ulcerative
tofacitinib
guidelines for drug use
canada
heart diseases
neoplasms
thrombosis
Janus Kinase Inhibitors
Janus Kinase Inhibitors
patient education handout
arthritis, psoriatic
serious infection

---
https://www.has-sante.fr/jcms/p_3337941/fr/xeljanz-tofacitinib-arthrite-juvenile-idiopathique-polyarticulaire
2022
France
evaluation of the transparency committee
unknown (origin)
indicators and reagents
arthritis, juvenile
rheumatoid arthritis, systemic juvenile
tofacitinib
Arthritis
indicators
traction
arthritis, nos
Xeljanz
indication of

---
https://www.has-sante.fr/jcms/p_3337944/fr/xeljanz-tofacitinib-arthrite-juvenile
2022
false
false
false
France
evaluation of the transparency committee
tofacitinib
Arthritis
arthritis, juvenile
Xeljanz
arthritis, nos

---
https://ansm.sante.fr/informations-de-securite/xeljanz-tofacitinib-augmentation-du-risque-devenements-cardiovasculaires-indesirables-majeurs-et-de-tumeurs-malignes-avec-lutilisation-de-tofacitinib-en-comparaison-aux-antitnf-alpha
2021
false
false
false
France
French
pharmacovigilance note
tofacitinib
cardiovascular diseases
risk
neoplasms
tofacitinib
tofacitinib
arthritis, rheumatoid
major adverse cardiovascular events
pyrimidines
pyrroles
piperidines
pyrimidines
pyrroles
piperidines

---
https://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2021/75315a-fra.php
2021
false
false
false
Canada
French
English
drug information
tofacitinib
neoplasms
heart diseases
arthritis, rheumatoid
arthritis, psoriatic
administration, oral
colitis, ulcerative
pyrimidines
pyrroles
piperidines

---
https://ansm.sante.fr/informations-de-securite/xeljanz-tofacitinib-les-resultats-preliminaires-dun-essai-clinique-indiquent-une-augmentation-du-risque-devenements-cardiovasculaires-et-de-tumeurs-malignes-en-comparaison-aux-anti-tnf-alpha
2021
false
false
false
France
French
clinical trials as topic
tofacitinib
neoplasms
cardiovascular diseases
risk
Janus Kinase Inhibitors
arthritis, rheumatoid
tofacitinib
pharmacovigilance note
pyrimidines
pyrroles
piperidines

---
https://www.has-sante.fr/jcms/p_3182797
2020
France
evaluation of the transparency committee
Xeljanz
tofacitinib

---
https://ansm.sante.fr/uploads/2020/10/30/20201030-dhpc-xeljanz.pdf
2020
false
false
false
France
French
tofacitinib
guidelines for drug use
administration, oral
protein kinase inhibitors
protein kinase inhibitors
risk factors
thrombosis
embolism and thrombosis
Drug-Related side effects and adverse reactions
tofacitinib
arthritis, rheumatoid
arthritis, psoriatic
colitis, ulcerative
venous thromboembolism
tofacitinib
pyrimidines
pyrroles
piperidines
pyrimidines
pyrroles
piperidines

---
http://www.cri-net.com/ckfinder/userfiles/files/fiches-pratiques/JAKI-octobre2019/JAK_18_Spondyloarthrites_MAJ_220719.pdf
2019
false
false
false
France
adult
tofacitinib
tofacitinib
administration, oral
baricitinib
baricitinib
spondylitis, ankylosing
arthritis, psoriatic
guideline
Janus Kinase Inhibitors
spondylarthropathies
pyrimidines
pyrroles
piperidines
azetidines
sulfonamides

---
http://www.cri-net.com/ckfinder/userfiles/files/fiches-pratiques/JAKI-octobre2019/JAK_09_Digestif_Hepatiq_MAJ_220719.pdf
2019
false
false
false
France
Janus Kinase Inhibitors
hepatic insufficiency
hepatitis B
hepatitis C
tofacitinib
baricitinib
Alanine aminotransferase outside reference range (finding)
transaminases
intestinal perforation
arthritis, rheumatoid
guideline
pyrimidines
pyrroles
piperidines
azetidines
sulfonamides

---
http://www.cri-net.com/ckfinder/userfiles/files/fiches-pratiques/JAKI-octobre2019/JAK_07_Cancer_MAJ_220719.pdf
2019
false
false
false
France
neoplasms
risk
Janus Kinase Inhibitors
Janus Kinase Inhibitors
tofacitinib
baricitinib
guideline
arthritis, rheumatoid
pyrimidines
pyrroles
piperidines
azetidines
sulfonamides

---
http://www.cri-net.com/ckfinder/userfiles/files/fiches-pratiques/JAKI-octobre2019/JAK_06_%20Cardio_MAJ_220719.pdf
2019
false
false
false
France
Janus Kinase Inhibitors
cardiovascular agents
anticoagulants
tofacitinib
baricitinib
cholesterol
Janus Kinase Inhibitors
risk
risk factors
drug interactions
guideline
arthritis, rheumatoid
cardiovascular diseases
pyrimidines
pyrroles
piperidines
azetidines
sulfonamides

---
XELJANZ / XELJANZ XR (tofacitinib) - Risk of Thrombosis
https://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2019/71766a-fra.php
2019
false
false
false
Canada
French
English
tofacitinib
thrombosis
risk
pharmacovigilance note
tofacitinib
pulmonary embolism
deep vein thrombosis
guidelines for drug use
arthritis, rheumatoid
arthritis, psoriatic
colitis, ulcerative
risk factors
patients guideline
venous thrombosis
pyrimidines
pyrroles
piperidines

---
https://www.has-sante.fr/jcms/c_2912419/fr/xeljanz
2019
false
false
false
France
administration, oral
treatment outcome
insurance, health, reimbursement
tofacitinib
tofacitinib citrate
colitis, ulcerative
protein kinase inhibitors
janus kinases
adult
Tyrosine Kinase Inhibitors
evaluation of the transparency committee
tofacitinib
pyrimidines
pyrroles
piperidines

---
https://www.ansm.sante.fr/actualites/restriction-dutilisation-du-xeljanz-tofacitinib
2019
false
false
false
France
French
guidelines for drug use
tofacitinib
protein kinase inhibitors
arthritis, rheumatoid
arthritis, psoriatic
colitis, ulcerative
administration, oral
tofacitinib
pulmonary embolism
tofacitinib
protein kinase inhibitors
pyrimidines
pyrroles
piperidines
pyrimidines
pyrroles
piperidines

---
https://ansm.sante.fr/informations-de-securite/xeljanz-tofacitinib-ne-plus-prescrire-10-mg-deux-fois-par-jour-chez-les-patients-ayant-un-risque-eleve-dembolie-pulmonaire
2019
false
false
false
France
French
administration, oral
tofacitinib
pharmacovigilance note
guidelines for drug use
pulmonary embolism
risk
arthritis, rheumatoid
tofacitinib
risk assessment
risk factors
tofacitinib
colitis, ulcerative
pyrimidines
pyrroles
piperidines
pyrimidines
pyrroles
piperidines

---
https://www.ansm.sante.fr/actualites/xeljanz-tofacitinib-lansm-demande-aux-professionnels-de-sante-et-aux-patients-de-bien-respecter-la-dose-autorisee-dans-le-traitement-de-la-polyarthrite-rhumatoide
2019
false
false
false
France
French
administration, oral
pharmacovigilance note
tofacitinib citrate
arthritis, rheumatoid
pulmonary embolism
tofacitinib citrate
tofacitinib
risk factors
tofacitinib
tofacitinib
pyrimidines
pyrroles
piperidines
pyrimidines
pyrroles
piperidines

---
Clinical trial finds an increased risk of blood clots in the lungs and of death in rheumatoid arthritis patients taking high dose of tofacitinib (sold as Xeljanz or Xeljanz XR)
https://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2019/69336a-fra.php
2019
false
false
false
Canada
French
English
pharmacovigilance note
arthritis, rheumatoid
tofacitinib
administration, oral
tofacitinib
protein kinase inhibitors
tofacitinib
pulmonary embolism
protein kinase inhibitors
pyrimidines
pyrroles
piperidines
pyrimidines
pyrroles
piperidines

---
http://www.cri-net.com/ckfinder/userfiles/files/fiches-pratiques/JAKI-octobre2019/JAK_08_Aff%20Hemato_MAJ_200819.pdf
2019
false
false
false
France
Janus Kinase Inhibitors
baricitinib
tofacitinib
Janus Kinase Inhibitors
risk factors
blood cell count
continuity of patient care
neutropenia
lymphopenia
anemia
algorithms
guideline
hematologic diseases
lymphoma
arthritis, rheumatoid
azetidines
sulfonamides
pyrimidines
pyrroles
piperidines

---
http://www.cri-net.com/fiches-pratiques-et-recommandations/prise-en-charge-patients-JAKi
2018
false
false
false
France
continuity of patient care
pregnancy
vaccination
travel
virus diseases
bacterial infections
cardiovascular diseases
neoplasms
lymphoma
digestive system diseases
hematologic diseases
dental care
surgical procedures, operative
tofacitinib
baricitinib
drug therapy, combination
arthritis, rheumatoid
Contraindications, Drug
drug interactions
Evidence-Based medicine
baricitinib
tofacitinib
guidelines for drug use
case management
Janus Kinase Inhibitors
pyrimidines
pyrroles
piperidines
azetidines
sulfonamides

---
https://www.has-sante.fr/portail/jcms/c_2894923/en/xeljanz
2018
false
false
false
France
administration, oral
arthritis, psoriatic
adult
treatment outcome
insurance, health, reimbursement
protein kinase inhibitors
evaluation of the transparency committee
tofacitinib
pyrimidines
pyrroles
piperidines

---
https://www.has-sante.fr/portail/jcms/c_2798163/fr/xeljanz-tofacitinib-anti-jak-1-et-3
https://www.has-sante.fr/portail/jcms/c_2798163/fr/xeljanz
2017
false
false
false
France
French
tofacitinib
treatment outcome
tofacitinib
adult
arthritis, rheumatoid
drug therapy, combination
methotrexate
administration, oral
continuity of patient care
protein kinase inhibitors
protein kinase inhibitors
aged
Product containing tofacitinib (medicinal product)
Tofacitinib 5mg tablet (product)
guidelines for drug use
evaluation of the transparency committee
janus kinase 1
janus kinase 3
insurance, health, reimbursement
risk
Tyrosine Kinase Inhibitors
tofacitinib
pyrimidines
pyrroles
piperidines
pyrimidines
pyrroles
piperidines

---
https://www.ema.europa.eu/medicines/human/EPAR/Xeljanz
2017
false
false
false
United Kingdom
French
English
syndication feed
summary of product characteristics
package leaflet
drug evaluation
tofacitinib
drug approval
europe
treatment outcome
tofacitinib
adult
arthritis, rheumatoid
drug therapy, combination
methotrexate
administration, oral
continuity of patient care
drug monitoring
janus kinases
pregnancy
breast feeding
drug interactions
protein kinase inhibitors
protein kinase inhibitors
product surveillance, postmarketing
aged
drug evaluation, preclinical
Product containing tofacitinib (medicinal product)
Tofacitinib 5mg tablet (product)
Tyrosine Kinase Inhibitors
tofacitinib
pyrimidines
pyrroles
piperidines
pyrimidines
pyrroles
piperidines

---
https://www.revmed.ch/RMS/2014/RMS-N-414/Rhumatologie-Une-nouvelle-option-therapeutique-dans-la-prise-en-charge-de-l-inflammation-chronique-en-rhumatologie-les-inhibiteurs-des-Janus-kinases
2014
false
false
false
Switzerland
piperidines
journal article
tofacitinib
protein kinase inhibitors
pyrimidines
pyrroles
tofacitinib
protein kinase inhibitors
piperidines
pyrimidines
pyrroles
arthritis, rheumatoid

---
Nous contacter.
02/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.