Preferred Label : Tofacitinib;
NCIt synonyms : Tasocitinib; 3-((3R,4R)-4-Methyl-3-(Methyl(7H-Pyrrolo(2,3-D)Pyrimidin-4-yl)Amino)Piperidin-1-yl)-3-Oxopropanenitrile;
NCIt related terms : JAK inhibitors: tofacitinib;
NCIt definition : An orally available inhibitor of Janus kinases (JAK), with immunomodulatory and anti-inflammatory
activities. Upon administration, tofacitinib binds to JAK and prevents the activation
of the JAK-signal transducers and activators of transcription (STAT) signaling pathway.
This may decrease the production of pro-inflammatory cytokines, such as interleukin
(IL)-6, -7, -15, -21, interferon-alpha and -beta, and may prevent both an inflammatory
response and the inflammation-induced damage caused by certain immunological diseases.
JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis,
immunity and inflammation.;
UNII : 87LA6FU830;
InChIKey : UJLAWZDWDVHWOW-YPMHNXCESA-N;
CAS number : 477600-75-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 477600-75-2
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G-SRS /a ;
Molecule name : CP-690,550 Free Base; CP-690550;
Chemical formula : C16H20N6O;
Codes from synonyms : 502;
Origin ID : C95800;
UMLS CUI : C2930696;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
