Preferred Label : Tofacitinib Citrate;
NCIt synonyms : Tasocitinib Citrate; 1-Piperidinepropanenitrile, 4-Methyl-3-(Methyl-7H-Pyrrolo(2,3-d)Pyrimidin-4-ylamino)-Beta-Oxo-,
(3R,4R)-, 2-Hydroxy-1,2,3-Propanetricarboxylate (1:1);
NCIt related terms : Xeljanz;
NCIt definition : The citrate salt form of tofacitinib, an orally bioavailable inhibitor of Janus kinases
(JAK), with immunomodulatory and anti-inflammatory activities. Upon oral administration,
tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers
and activators of transcription (STAT) signaling pathway. This may decrease the production
of pro-inflammatory cytokines, such as interleukin (IL)-6, -7, -15, -21, interferon-alpha
(IFN-a) and -beta (IFN-b), and may prevent both an inflammatory response and the inflammation-induced
damage caused by certain immunological diseases. JAK kinases are intracellular enzymes
involved in signaling pathways affecting hematopoiesis, immunity and inflammation.;
UNII : O1FF4DIV0D;
InChIKey : SYIKUFDOYJFGBQ-YLAFAASESA-N;
CAS number : 540737-29-9;
Drug name : Xeljanz;
Molecule name : CP-690,550-10;
Chemical formula : C16H20N6O.C6H8O7;
Origin ID : C95801;
UMLS CUI : C2987431;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
