tumor necrosis factor-alpha

Preferred Label : tumor necrosis factor-alpha;

MeSH definition : Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.;

MeSH synonym : tumor necrosis factor; cachectin tumor necrosis factor; cachectin-tumor necrosis factor; TNFalpha; tumor necrosis factor ligand superfamily member 2; cachectin; tnf superfamily, member 2; tumor necrosis factor alpha; TNF-alpha;

Wikipedia link : https://en.wikipedia.org/wiki/Tumor necrosis factor;

Is substance : O;

Details

Origin ID

D014409;

UMLS CUI

C1456820;

ATC code(s)
- Tumor necrosis factor alpha (TNF-α) inhibitors [ATC Code]
- tasonermin [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Recombinant Tumor Necrosis Factor-Alpha [NCIt concept]
- TNF wt Allele [NCIt concept]
- Tasonermin (substance) [SNOMED CT concept]
- Tumor Necrosis Factor (CET) [NCIt concept]
- Tumor Necrosis Factor Measurement [NCIt concept]
- Tumor necrosis factor [OMIM gene]
- Tumor necrosis factor.alpha [LOINC component]
- tasonermin [International Nonproprietary Name]
- tasonermin [ATC Code]
- tumor necrosis factor [HGNC gene]
- tumor necrosis factor alpha [COVID-19 Thesaurus concept]
- tumor necrosis factor receptor binding [GO term]
Currated CISMeF NLP mapping
- Alpha tumor necrosis factor [MedDRA LLT]
- Alpha tumour necrosis factor [MedDRA Preferred Term]
- Recombinant Tumor Necrosis Factor Family Protein [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor necrosis factor [LOINC component]
- Tumor necrosis factor (substance) [SNOMED CT concept]
- Tumor necrosis factor alpha (substance) [SNOMED CT concept]
- tumor necrosis factor [SNOMED Notion]
- tumor necrosis factor [Artificial nutrition thesaurus concept]
- tumor necrosis factor alpha [SNOMED Notion]
Indexing information
- 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one [MeSH Supplementary Concept]
- 1-(3-(4-morpholinyl)propyl)-4-(4-fluorophenyl)-5-(4-pyridyl)imidazole [MeSH Supplementary Concept]
- 1-(4-aminophenyl)methyl-3-(3-nitrophenyl)-1,3-dihydroimidazo(4,5-b)pyridine-2-one [MeSH Supplementary Concept]
- 2,6-piperidinedithione [MeSH Supplementary Concept]
- 2-(3-tert-butyl-1-phenyl-1H-pyrazol-5-ylamino)-N'-((4-(2-morpholinoethoxy)naphthalen-1-yl)methylene)acetohydrazide [MeSH Supplementary Concept]
- 2-(3-tert-butyl-1-phenyl-1H-pyrazol-5-ylamino)-N'-(4-chlorobenzylidene)acetohydrazide [MeSH Supplementary Concept]
- 2-amino-6-chloro-9-((5-dihydroxyboryl)pentyl)purine [MeSH Supplementary Concept]
- 3,6'-dithiothalidomide [MeSH Supplementary Concept]
- 3-(1-(6,7-diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl)-1,6-dimethyl-2,4-(1H,3H)-quinazolinedione [MeSH Supplementary Concept]
- 3-(hydroxymethyl)-6-(1-hydroxy-1-methyltridecyl)-4-methoxy-2H-pyran-2-one [MeSH Supplementary Concept]
- 3-chloro-4-dichloromethyl-5-dichloromethylene-2,4-dihydroxycyclopent-2-enone [MeSH Supplementary Concept]
- 5,N-dihydroxythalidomide [MeSH Supplementary Concept]
- AP301 peptide [MeSH Supplementary Concept]
- BF02 protein [MeSH Supplementary Concept]
- CDP 571 [MeSH Supplementary Concept]
- CGP 47969A [MeSH Supplementary Concept]
- GLA 27 [MeSH Supplementary Concept]
- N-(4-(2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide [MeSH Supplementary Concept]
- PEGylated tumor necrosis factor alpha receptor 1 [MeSH Supplementary Concept]
- RU 36156 [MeSH Supplementary Concept]
- Ro 45-2081 [MeSH Supplementary Concept]
- TIPE1 protein, mouse [MeSH Supplementary Concept]
- TJU 103 [MeSH Supplementary Concept]
- TNFAIP1 protein, human [MeSH Supplementary Concept]
- TNFAIP3 protein, human [MeSH Supplementary Concept]
- TNFAIP6 protein, human [MeSH Supplementary Concept]
- TNFAIP8L1 protein, human [MeSH Supplementary Concept]
- Tnfaip1 protein, mouse [MeSH Supplementary Concept]
- Tsg-5 protein, mouse [MeSH Supplementary Concept]
- UTL-5b [MeSH Supplementary Concept]
- afelimomab [MeSH Supplementary Concept]
- agallochaol Q [MeSH Supplementary Concept]
- copper smelter dust [MeSH Supplementary Concept]
- dihydro-4-hydroxy-3-icosylidene-5-methylidenefuran-2(3H)-one [MeSH Supplementary Concept]
- pirfenidone [MeSH Supplementary Concept]
- procurcumenol [MeSH Supplementary Concept]
- tetrafluorothalidomide [MeSH Supplementary Concept]
- tipalpha protein, helicobacter pylori [MeSH Supplementary Concept]
- trichodimerol [MeSH Supplementary Concept]
Manual BTNT mappings - CISMeF
- tasonermin [International Nonproprietary Name]
Metaterm(s)
- oncology [CISMeF Metaterm]
Record concept(s)
- tumor necrosis factor-alpha [MeSH concept]
Related MeSH Supplementary Concept(s)
- 58 kDa tumor necrosis factor-inducing protein, mycobacterium tuberculosis [MeSH Supplementary Concept]
- F 4168 [MeSH Supplementary Concept]
- F 4614 [MeSH Supplementary Concept]
- His-TRAIL protein, recombinant [MeSH Supplementary Concept]
- LK-805 [MeSH Supplementary Concept]
- LZ-TRAIL protein, recombinant [MeSH Supplementary Concept]
- PEG-modified tumor necrosis factor-alpha [MeSH Supplementary Concept]
- RM4-TNF protein, recombinant [MeSH Supplementary Concept]
- TNF protein, human [MeSH Supplementary Concept]
- TNF-SAM2 [MeSH Supplementary Concept]
- TNF-selectokine [MeSH Supplementary Concept]
- Tnf protein, mouse [MeSH Supplementary Concept]
- XENP 1595 [MeSH Supplementary Concept]
- mTNF-PADRE [MeSH Supplementary Concept]
- mutein 3 [MeSH Supplementary Concept]
- mutein 5 [MeSH Supplementary Concept]
- mutein 6 [MeSH Supplementary Concept]
- mutein TNF 471 [MeSH Supplementary Concept]
- serum tumorlytic factor [MeSH Supplementary Concept]
- tumor necrosis factor (1-12) [MeSH Supplementary Concept]
- tumor necrosis factor (1-26) [MeSH Supplementary Concept]
- tumor necrosis factor (41-62) [MeSH Supplementary Concept]
- tumor necrosis factor (78-96) [MeSH Supplementary Concept]
- tumor necrosis factor alpha (36-68) [MeSH Supplementary Concept]
- tumor necrosis factor alpha (70-80) [MeSH Supplementary Concept]
- tumor necrosis factor precursor [MeSH Supplementary Concept]
- tumor necrosis factor-alpha, CNGRC fusion protein, human [MeSH Supplementary Concept]
- tumor necrosis factor-alpha, CNGRC fusion protein, mouse [MeSH Supplementary Concept]
See also
- Adalimumab [MeSH Descriptor]
- Certolizumab Pegol [MeSH Descriptor]
- Infliximab [MeSH Descriptor]
- necrosis [MeSH Descriptor]
- tumor lysis syndrome [MeSH Descriptor]
See also inter- (CISMeF)
- Product containing tasonermin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Tumor necrosis factor (substance) [SNOMED CT concept]
- Tumor necrosis factor alpha (substance) [SNOMED CT concept]
- Tumor necrosis factor.alpha [LOINC component]
- tumor necrosis factor [SNOMED Notion]
- tumor necrosis factor alpha [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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