NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to the
endogenous cytokine tumor necrosis factor-alpha with antineoplastic properties. Tumor
necrosis factor-alpha binds to and activates death receptors on the cell surface,
resulting in apoptosis and cell death by the p53-independent extrinsic pathway. This
agent also disrupts tumor vascularization. (NCI04);
UNII : X2C8Z061MB;
CAS number : 308079-78-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 308079-78-9
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