Recombinant Tumor Necrosis Factor-Alpha

Preferred Label : Recombinant Tumor Necrosis Factor-Alpha;

NCIt synonyms : TNF-Alpha; Cachectin; Tumor Necrosis Factor (TNF-alpha); TNFA; Therapeutic Tumor Necrosis Factor-Alpha;

NCIt related terms : SONERMIN;

NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine tumor necrosis factor-alpha with antineoplastic properties. Tumor necrosis factor-alpha binds to and activates death receptors on the cell surface, resulting in apoptosis and cell death by the p53-independent extrinsic pathway. This agent also disrupts tumor vascularization. (NCI04);

UNII : X2C8Z061MB;

CAS number : 308079-78-9;

NSC code : 697068;

Details

Origin ID

C913;

UMLS CUI

C1522669;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Tumor Necrosis Factor [NCIt concept]
- Cyclophosphamide/Interleukin-2/Monoclonal Antibody OKT3/Tumor Necrosis Factor [NCIt concept]
- Cyclophosphamide/Interleukin-2/Tumor Necrosis Factor [NCIt concept]
- Dactinomycin/Tumor Necrosis Factor [NCIt concept]
- Etoposide/Tumor Necrosis Factor [NCIt concept]
- Interferon Alfa/Interleukin-2/Tumor Necrosis Factor [NCIt concept]
- Interferon Gamma/Interleukin-1-Beta/Interleukin-2/Sargramostim/Tumor Necrosis Factor [NCIt concept]
- Interferon Gamma/Interleukin-2/Melphalan/Tumor Necrosis Factor [NCIt concept]
- Interferon Gamma/Melphalan/Tumor Necrosis Factor [NCIt concept]
- Interferon Gamma/Tumor Necrosis Factor [NCIt concept]
- Interleukin-2/Tumor Necrosis Factor [NCIt concept]
- Melphalan/Tumor Necrosis Factor [NCIt concept]
- Sargramostim/Tumor Necrosis Factor [NCIt concept]
- interleukin-2/Monoclonal Antibody OKT3/Tumor Necrosis Factor [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients