Recombinant Tumor Necrosis Factor Family Protein

Preferred Label : Recombinant Tumor Necrosis Factor Family Protein;

NCIt synonyms : Tumor Necrosis Factor Family Protein; Tumor Necrosis Factors; Therapeutic Tumor Necrosis Factor Family Protein;

NCIt related terms : tumor necrosis factor; TNF;

NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to one of a number of endogenous tumor necrosis factor (TNF) proteins. TNF family cytokines bind to and activate specific cell-surface receptors, thereby mediating inflammatory processes, cell proliferation, immunity, angiogenesis, and tumor cell cytotoxicity. One primary antitumor effect of TNFs involves stimulation of T cell-mediated antitumor cytotoxicity.;

Alternative definition : NCI-GLOSS: A protein made by white blood cells in response to an antigen (substance that causes the immune system to make a specific immune response) or infection. Tumor necrosis factor can also be made in the laboratory. It may boost a person's immune response, and also may cause necrosis (cell death) of some types of tumor cells. Tumor necrosis factor is being studied in the treatment of some types of cancer. It is a type of cytokine.;

NSC code : 349993; 604175;

Codes from synonyms : CDR0000045290; CDR0000044471;

Details

Origin ID

C1941;

UMLS CUI

C1522668;

Automatic exact mappings (from CISMeF team)
- Tumor necrosis factor [OMIM gene]
- Tumor necrosis factor.alpha [LOINC component]
- tumor necrosis factor [HGNC gene]
- tumor necrosis factor receptor binding [GO term]
Currated CISMeF NLP mapping
- Tumor necrosis factor [LOINC component]
- Tumor necrosis factor (substance) [SNOMED CT concept]
- tumor necrosis factor [Artificial nutrition thesaurus concept]
- tumor necrosis factor [SNOMED Notion]
- tumor necrosis factor-alpha [MeSH Descriptor]
- tumor necrosis factor-alpha [MeSH concept]
- tumor necrosis factors [MeSH concept]
False automatic mappings
- tumor necrosis factor (1-12) [MeSH concept]
- tumor necrosis factor (1-12) [MeSH Supplementary Concept]
- tumor necrosis factor (1-26) [MeSH concept]
- tumor necrosis factor (1-26) [MeSH Supplementary Concept]
- tumor necrosis factor (41-62) [MeSH concept]
- tumor necrosis factor (41-62) [MeSH Supplementary Concept]
- tumor necrosis factor (78-96) [MeSH concept]
- tumor necrosis factor (78-96) [MeSH Supplementary Concept]
See also inter- (CISMeF)
- tumor necrosis factors [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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