Preferred Label : pyrimidinones;
MeSH definition : Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones
(or 4-hydroxypyrimidines) with the general formula C4H4N2O.;
MeSH synonym : Pyrimidinone;
Related MeSH term : pyrimidones; Pyrimidone;
Wikipedia link : https://en.wikipedia.org/wiki/Pyrimidone;
Is substance : O;
Origin ID : D011744;
UMLS CUI : C0034290;
Allowable qualifiers
Record concept(s)
Related MeSH Supplementary Concept(s)
- ADS J13 [MeSH Supplementary Concept]
- AP 155 [MeSH Supplementary Concept]
- AS 35 [MeSH Supplementary Concept]
- AZ3976 [MeSH Supplementary Concept]
- AZD3241 [MeSH Supplementary Concept]
- AZD3965 [MeSH Supplementary Concept]
- BL 5255 [MeSH Supplementary Concept]
- CH 150 [MeSH Supplementary Concept]
- CM-414 [MeSH Supplementary Concept]
- CPW 399 [MeSH Supplementary Concept]
- DH 6471 [MeSH Supplementary Concept]
- FK 664 [MeSH Supplementary Concept]
- GSK5750 [MeSH Supplementary Concept]
- GSK621 [MeSH Supplementary Concept]
- HN-37 [MeSH Supplementary Concept]
- ICG 001 [MeSH Supplementary Concept]
- JBIR-68 [MeSH Supplementary Concept]
- LCQ789 [MeSH Supplementary Concept]
- LIT-927 [MeSH Supplementary Concept]
- MBX-500 [MeSH Supplementary Concept]
- MC1742 [MeSH Supplementary Concept]
- MC1838 [MeSH Supplementary Concept]
- MC1839 [MeSH Supplementary Concept]
- MZ 472 [MeSH Supplementary Concept]
- ND-630 [MeSH Supplementary Concept]
- ND-646 [MeSH Supplementary Concept]
- PNP405 [MeSH Supplementary Concept]
- R 59022 [MeSH Supplementary Concept]
- RAMX3 [MeSH Supplementary Concept]
- RX-P873 [MeSH Supplementary Concept]
- SAR405 [MeSH Supplementary Concept]
- SJ3366 [MeSH Supplementary Concept]
- SPL-334 [MeSH Supplementary Concept]
- TAK 733 [MeSH Supplementary Concept]
- TGX 221 [MeSH Supplementary Concept]
- TKI-31 [MeSH Supplementary Concept]
- TPN171 [MeSH Supplementary Concept]
- TPN729 [MeSH Supplementary Concept]
- UCF 101 [MeSH Supplementary Concept]
- Y 40018 [MeSH Supplementary Concept]
- Y 40079 [MeSH Supplementary Concept]
- YH 1885 [MeSH Supplementary Concept]
- YM 976 [MeSH Supplementary Concept]
- damvar [MeSH Supplementary Concept]
- icilin [MeSH Supplementary Concept]
- probon [MeSH Supplementary Concept]
- vicine [MeSH Supplementary Concept]
Semantic type(s)
Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones
(or 4-hydroxypyrimidines) with the general formula C4H4N2O.
https://www.has-sante.fr/jcms/p_3146424/fr/tafinlar-mekinist
2020
false
false
false
France
BRAF V600E mutation positive
dabrafenib
dabrafenib
treatment outcome
antineoplastic combined chemotherapy protocols
trametinib
antineoplastic agents
protein kinase inhibitors
trametinib
carcinoma, non-small-cell lung
BRAF protein, human
evaluation of the transparency committee
imidazoles
oximes
pyridones
pyrimidinones
proto-oncogene proteins b-raf
---
https://www.has-sante.fr/portail/jcms/c_2911595/fr/mekinist-tafinlar
2019
false
true
false
false
France
trametinib
dabrafenib
treatment outcome
melanoma
administration, oral
antineoplastic combined chemotherapy protocols
adult
antineoplastic agents
protein kinase inhibitors
melanoma
BRAF V600 Mutation
evaluation of the transparency committee
pyridones
pyrimidinones
imidazoles
oximes
---
https://www.has-sante.fr/portail/jcms/c_2835407/fr/mekinist-tafinlar
https://www.has-sante.fr/portail/jcms/c_2835407/fr/tafinlar-dabrafenib-en-association-a-mekinist-trametinib-inhibiteurs-de-la-proteine-kinase
2018
false
false
false
false
France
French
evaluation of the transparency committee
dabrafenib
dabrafenib
antineoplastic combined chemotherapy protocols
treatment outcome
administration, oral
carcinoma, non-small-cell lung
BRAF V600 Mutation
trametinib
trametinib
antineoplastic agents
antineoplastic agents
protein kinase inhibitors
protein kinase inhibitors
guidelines for drug use
pyridones
pyrimidinones
pyridones
pyrimidinones
imidazoles
oximes
imidazoles
oximes
---
The risk of colitis and gastrointestinal perforation has been added to the Warnings
and Precautions and Adverse Reactions sections of the Canadian product monograph for
Mekinist (trametinib)
https://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2017-01-page4-fra.php#pmu
2017
false
false
false
Canada
French
English
pharmacovigilance note
administration, oral
journal article
trametinib
risk factors
trametinib
Digestive System Perforation
intestinal perforation
colitis
socioeconomic factors
pyridones
pyrimidinones
---
http://www.has-sante.fr/portail/jcms/c_2606857/fr/mekinist
http://www.has-sante.fr/portail/jcms/c_2606857/fr/mekinist-trametinib-inhibiteur-de-proteine-kinase
2016
false
false
false
France
French
evaluation of the transparency committee
administration, oral
trametinib
trametinib
trametinib
adult
antineoplastic combined chemotherapy protocols
antineoplastic agents
antineoplastic agents
melanoma
neoplasm metastasis
Metastatic Melanoma
Unresectable Malignant Neoplasm
melanoma
MAP kinase kinase 1
MAP kinase kinase 2
mutation
proto-oncogene proteins b-raf
dabrafenib
guidelines for drug use
Tyrosine Kinase Inhibitors
pyridones
pyrimidinones
pyridones
pyrimidinones
imidazoles
oximes
---
https://www.ema.europa.eu/medicines/human/EPAR/Mekinist
2014
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
trametinib
drug approval
europe
trametinib
trametinib
adult
melanoma
antineoplastic agents
antineoplastic agents
mutation
proto-oncogene proteins b-raf
administration, oral
drug monitoring
product surveillance, postmarketing
aged
drug interactions
contraception
pregnancy
breast feeding
protein kinase inhibitors
protein kinase inhibitors
MAP kinase kinase 1
MAP kinase kinase 2
drug evaluation, preclinical
Tyrosine Kinase Inhibitors
pyridones
pyrimidinones
pyridones
pyrimidinones
---
https://www.ema.europa.eu/medicines/human/EPAR/Sebivo
2011
United Kingdom
French
English
syndication feed
hepatitis B, chronic
antiviral agents
antiviral agents
treatment outcome
drug evaluation
telbivudine
thymidine
drug evaluation
summary of product characteristics
package leaflet
Telbivudine
nucleosides
pyrimidinones
nucleosides
pyrimidinones
---
https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2008/14517a-fra.php
2008
Canada
French
English
hepatitis B, chronic
peripheral nervous system diseases
drug therapy, combination
polyethylene glycols
antiviral agents
peginterferon alfa-2a
polyethylene glycols
thymidine
pharmacovigilance note
Telbivudine
nucleosides
pyrimidinones
---
https://www.cadth.ca/sites/default/files/cdr/complete/cdr_complete_Sebivo_September-26-2007_f.pdf
2007
Canada
French
hepatitis B, chronic
telbivudine
drug evaluation
thymidine
Telbivudine
nucleosides
pyrimidinones
---