EGFR NP_005219.2:p.L858R

Preferred Label : EGFR NP_005219.2:p.L858R;

NCIt synonyms : EGFR p.Leu858Arg; EGFR p.L858R; Receptor Tyrosine-Protein Kinase erbB-1 L858R; EGFR Leu858Arg; Proto-Oncogene c-ErbB-1 L858R; EGFR L858R; Epidermal Growth Factor Receptor L858R; NP_005219.2:p.Leu858Arg; EGFR NP_005219.2:p.Leu858Arg; EGFR Exon 21 L858R Mutation; EGFR Activating Mutation L858R; EGFR Exon 21 Substitution Mutation L858R;

NCIt related terms : Exon 21 Leu858Arg;

NCIt definition : A change in the amino acid residue at position 858 in the epidermal growth factor receptor protein where leucine has been replaced by arginine.;

Details

Origin ID

C98515;

UMLS CUI

C3274204;

Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
concept_is_in_subset
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Lung Squamous Cell Carcinoma and Lung Adenocarcinoma Baseline Form [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_sequence_variation_encoded_by_gene_mutant
- Activating EGFR Gene Mutation [NCIt concept]
- EGFR Gene Mutation [NCIt concept]
- EGFR NM_005228.3:c.2572_2573delinsAG [NCIt concept]
- EGFR NM_005228.3:c.2573T>G [NCIt concept]
- EGFR NM_005228.3:c.2573_2574delinsGT [NCIt concept]
gene_product_variant_of_gene_product
- Epidermal Growth Factor Receptor [NCIt concept]
is_target
- EGFR Inhibitor WJ13404 [NCIt concept]
- EGFR Inhibitor XZP-5809 [NCIt concept]
- EGFR Inhibitor XZP-5809 Tartrate [NCIt concept]
- EGFR Mutant-selective Inhibitor BLU-701 [NCIt concept]
- EGFR Mutant-selective Inhibitor FWD1509 MsOH [NCIt concept]
- EGFR Mutant-selective Inhibitor H002 [NCIt concept]
- EGFR Mutant-selective Inhibitor QLH11811 [NCIt concept]
- EGFR Mutant-specific Inhibitor CK-101 [NCIt concept]
- EGFR Mutant-specific Inhibitor ZN-e4 [NCIt concept]
- Lazertinib [NCIt concept]
- Osimertinib [NCIt concept]
- Osimertinib Mesylate [NCIt concept]
- Tigozertinib [NCIt concept]
molecular_abnormality_involves_gene
- EGFR Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients