" /> EGFR Inhibitor WJ13404 - CISMeF





Preferred Label : EGFR Inhibitor WJ13404;

NCIt definition : An orally bioavailable, fourth-generation epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, EGFR inhibitor WJ13404 targets, binds to, and inhibits the activity of EGFR, including wild-type EGFR and multiple EGFR resistance mutations, such as triple mutations Del19/T790M/C797S and L858R/T790M/C797S. This prevents EGFR-mediated signaling, which induces cell death and inhibits tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.;

Molecule name : WJ 13404; WJ-13404;

NCI Metathesaurus CUI : CL1905841;

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15/05/2024


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