Preferred Label : Andamertinib;
NCIt synonyms : Mutant-selective EGFR Inhibitor PLB1004; EGFR Mutant-selective Inhibitor PLB1004;
NCIt definition : An orally bioavailable, mono-anilino-pyrimidine, mutant-selective epidermal growth
factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral
administration, andamertinib targets, binds to and irreversibly inhibits the activity
of various EGFR mutations, including exon 20 insertion (Ex20ins) activating mutations,
the gatekeeper mutation T790M, ExDel19, and L858R. This prevents EGFR-mediated signaling,
induces cell death and inhibits tumor growth in tumor cells expressing these EGFR
mutations. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays
a key role in tumor cell proliferation and tumor vascularization.;
UNII : 5X3KAG7ZBW;
CAS number : 2254145-43-0;
Molecule name : PLB 1004; PLB-1004;
Origin ID : C209347;
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