Preferred Label : EGFR Mutant-selective Inhibitor FWD1509 MsOH;
NCIt synonyms : FWD1509 Methanesulfonic Acid;
NCIt definition : The methanesulfonic acid salt form of FWD1509, an orally bioavailable, irreversible,
small molecule, mutant-selective inhibitor of epidermal growth factor receptor (EGFR),
with potential antineoplastic activity. Upon oral administration, EGFR mutant-selective
inhibitor FWD1509 MsOH targets, binds to, and inhibits the activity of EGFR with exon20
insertion mutations, as well as L858R, exon19del and T790M mutations, thereby preventing
EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth
in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many
tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.
FWD1509 MsOH is able to cross the blood-brain barrier (BBB).;
NCI Metathesaurus CUI : CL1771137;
Origin ID : C182459;
UMLS CUI : C5667591;
Semantic type(s)
- concept_is_in_subset
- has_target
