Preferred Label : EGFR Inhibitor XZP-5809;
NCIt definition : An orally bioavailable third-generation inhibitor of certain epidermal growth factor
receptor (EGFR) activating mutations, including the resistance mutation T790M, and
the L858R and del 19 mutations, with potential antineoplastic activity. Upon oral
administration, EGFR inhibitor XZP-5809 specifically and irreversibly binds to and
inhibits selective EGFR mutations, which prevents EGFR mutant-mediated signaling and
leads to cell death in EGFR mutant-expressing tumor cells. This agent shows higher
activity against EGFR mutants compared with wild-type EGFR (WT EGFR). EGFR, a receptor
tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation
and tumor vascularization.;
Molecule name : XZP-5809; XZP 5809;
NCI Metathesaurus CUI : CL1648072;
Origin ID : C178585;
UMLS CUI : C5555144;
Semantic type(s)
- concept_is_in_subset
- has_target
