Preferred Label : Osimertinib;
NCIt synonyms : 2-Propenamide, N-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-; Mereletinib;
NCIt definition : A third-generation, orally available, irreversible, mutant-selective, epidermal growth
factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral
administration, osimertinib covalently binds to and inhibits the activity of numerous
mutant forms of EGFR, including the secondarily-acquired resistance mutation T790M,
L858R, and exon 19 deletions, thereby preventing EGFR-mediated signaling. This may
both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells.
EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role
in tumor cell proliferation and tumor vascularization. As this agent is selective
towards mutant forms of EGFR, its toxicity profile may be reduced when compared to
non-selective EGFR inhibitors which also inhibit wild-type EGFR.;
UNII : 3C06JJ0Z2O;
InChIKey : DUYJMQONPNNFPI-UHFFFAOYSA-N;
CAS number : 1421373-65-0;
Molecule name : AZD-9291; AZD 9291;
Codes from synonyms : 375;
Origin ID : C116377;
UMLS CUI : C4058811;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
