Preferred Label : EGFR Mutant-specific Inhibitor ZN-e4;
NCIt definition : An orally available selective inhibitor of certain epidermal growth factor receptor
(EGFR) activating mutations, including the resistance mutation T790M, with potential
antineoplastic activity. Upon administration, the EGFR mutant-specific inhibitor ZN-e4
specifically binds to and inhibits selective EGFR mutations, which prevents EGFR mutant-mediated
signaling and leads to cell death in EGFR mutant-expressing tumor cells. Compared
to other EGFR inhibitors, ZN-e4 may offer therapeutic benefits in tumors with T790M-mediated
drug resistance and may limit toxicities associated with non-selective EGFR inhibitors.
EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role
in tumor cell proliferation and tumor vascularization.;
Molecule name : ZN-e4; ZN e4; KP-673;
NCI Metathesaurus CUI : CL554308;
Origin ID : C153173;
UMLS CUI : C4727072;
Semantic type(s)
- concept_is_in_subset
- has_target
