GLP-1 Mimetics

Preferred Label : GLP-1 Mimetics;

NCIt synonyms : GLP-1 Analogue;

NCIt related terms : GLP-1 receptor agonist;

NCIt definition : Any of the analogues of the endogenous gastrointestinal hormone glucagon-like peptide-1 (GLP-1) with antihyperglycemic activity. GLP-1 mimetics mimic the activity of GLP-1 and thereby stimulate glucose-dependent secretion of insulin from pancreatic beta cells, suppress glucagon secretion from alpha cells, increase insulin sensitivity and inhibit gastric emptying thereby slowing absorption of nutrients and creating a satiating effect. Altogether, this lowers blood glucose levels. GLP-1 is rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4).;

Alternative definition : ACC/AHA: Select medications in this class have been shown to improve ASCVD outcomes, drive weight loss, and lower glucose.;

Details

Origin ID

C98085;

UMLS CUI

C1562104;

Automatic exact mappings (from CISMeF team)
- Substance with glucagon-like peptide 1 receptor agonist mechanism of action (substance) [SNOMED CT concept]
CISMeF manual mappings
- glucagon-like peptide 1 [MeSH Descriptor]
See also inter- (CISMeF)
- Glucagon-like peptide 1 receptor agonist (disposition) [SNOMED CT concept]
- Glucagon-like peptide-1 (GLP-1) analogues [ATC Code]
Semantic type(s)
- Hormone [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Glucagon-Like Peptide-1 Receptor Agonists [MeSH Descriptor]
- Product containing glucagon-like peptide 1 receptor agonist (product) [SNOMED CT concept]
- Substance with glucagon-like peptide 1 receptor agonist mechanism of action (substance) [SNOMED CT concept]
- incretin mimetics and incretin enhancers [CISMeF Querying Strategy]
concept_is_in_subset
- ACC/AHA COVID-19 Appendix Variables [NCIt concept]
- ACC/AHA Cardiovascular and Noncardiovascular Complications of COVID-19 Terminology [NCIt concept]
- Appendix 8: Pharmacological Therapy Terminology [NCIt concept]
- Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

You can consult :

recommendations
documents concerning education
documents for patients