Mismatch Repair Pathway

Preferred Label : Mismatch Repair Pathway;

NCIt synonyms : DNA Mismatch Repair Pathway;

NCIt related terms : Mismatch repair;

Alternative definition : KEGG: DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.;

KEGG ID : hsa03430;

Details

Origin ID

C91471;

UMLS CUI

C2984283;

See also inter- (CISMeF)
- dna mismatch repair [MeSH Descriptor]
- mismatch repair [GO term]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- DNA Mismatch Repair Protein Mlh1 [NCIt concept]
- DNA Mismatch Repair Protein Mlh3 [NCIt concept]
- DNA Mismatch Repair Protein Msh2 [NCIt concept]
- DNA Mismatch Repair Protein Msh3 [NCIt concept]
- DNA Mismatch Repair Protein Msh6 [NCIt concept]
- DNA Polymerase Delta Catalytic Subunit [NCIt concept]
- DNA Polymerase Delta Subunit 3 [NCIt concept]
- DNA Polymerase Epsilon Catalytic Subunit A [NCIt concept]
- Exonuclease 1 [NCIt concept]
- Mismatch Repair Endonuclease PMS2 [NCIt concept]
- Replication Factor C Subunit 1 [NCIt concept]
- Replication Factor C Subunit 2 [NCIt concept]
- Replication Factor C Subunit 3 [NCIt concept]
- Replication Factor C Subunit 4 [NCIt concept]
- Replication Factor C Subunit 5 [NCIt concept]
- Replication Protein A 14 kDa [NCIt concept]
- Replication Protein A 32 kDa Subunit [NCIt concept]
- Replication Protein A 70 kDa DNA-Binding Subunit [NCIt concept]
- Single-Stranded DNA-Binding Protein, Mitochondrial [NCIt concept]
pathway_has_gene_element
- EXO1 wt Allele [NCIt concept]
- MLH1 wt Allele [NCIt concept]
- MLH3 wt Allele [NCIt concept]
- MSH2 wt Allele [NCIt concept]
- MSH3 wt Allele [NCIt concept]
- MSH6 wt Allele [NCIt concept]
- PMS2 wt Allele [NCIt concept]
- POLD1 wt Allele [NCIt concept]
- POLD3 wt Allele [NCIt concept]
- POLE wt Allele [NCIt concept]
- RFC1 wt Allele [NCIt concept]
- RFC2 wt Allele [NCIt concept]
- RFC3 wt Allele [NCIt concept]
- RFC4 wt Allele [NCIt concept]
- RFC5 wt Allele [NCIt concept]
- RPA1 wt Allele [NCIt concept]
- RPA2 wt Allele [NCIt concept]
- RPA3 wt Allele [NCIt concept]
- SSBP1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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