Cardiac Muscle Contraction Pathway

Preferred Label : Cardiac Muscle Contraction Pathway;

NCIt related terms : Cardiac muscle contraction;

Alternative definition : KEGG: Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2 influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2 via Ca2 release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2 -induced Ca release (CICR) mechanism. Ca2 ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2 binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2 is pumped out of the cell by the Na /Ca2 exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2 -ATPase (SERCA) pumps on the non-junctional region of the SR.;

KEGG ID : hsa04260;

Details

Origin ID

C91467;

UMLS CUI

C2984279;

Automatic exact mappings (from CISMeF team)
- cardiac muscle contraction [GO term]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Actin, Alpha Cardiac Muscle 1 [NCIt concept]
- Calsequestrin-2 [NCIt concept]
- Cytochrome C Oxidase Subunit 1 [NCIt concept]
- Cytochrome C Oxidase Subunit 6A2, Mitochondrial [NCIt concept]
- Cytochrome C Oxidase Subunit 6C [NCIt concept]
- Cytochrome C Oxidase Subunit 7A-Related Protein, Mitochondrial [NCIt concept]
- Cytochrome b-c1 Complex Subunit 6, Mitochondrial [NCIt concept]
- Junctin-1 [NCIt concept]
- Myosin-6 [NCIt concept]
- Ryanodine Receptor 2 [NCIt concept]
- Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 [NCIt concept]
- Sodium/Calcium Exchanger 1 [NCIt concept]
- Sodium/Hydrogen Exchanger 1 [NCIt concept]
- Sodium/Hydrogen Exchanger 6 [NCIt concept]
- Sodium/Potassium-Transporting ATPase Subunit Alpha-1 [NCIt concept]
- Sodium/Potassium-Transporting ATPase Subunit Alpha-3 [NCIt concept]
- Sodium/Potassium-Transporting ATPase Subunit Beta-3 [NCIt concept]
- Tropomyosin Alpha-1 Chain [NCIt concept]
- Tropomyosin Alpha-3 Chain [NCIt concept]
- Tropomyosin Alpha-4 Chain [NCIt concept]
- Tropomyosin Beta Chain [NCIt concept]
- Troponin I, Cardiac Muscle [NCIt concept]
- Troponin T, Cardiac Muscle [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1S [NCIt concept]
pathway_has_gene_element
- ACTC1 wt Allele [NCIt concept]
- ASPH wt Allele [NCIt concept]
- ATP1A1 wt Allele [NCIt concept]
- ATP1A3 wt Allele [NCIt concept]
- ATP1B3 wt Allele [NCIt concept]
- ATP2A2 wt Allele [NCIt concept]
- CACNA1C wt Allele [NCIt concept]
- CACNA1D wt Allele [NCIt concept]
- CACNA1S wt Allele [NCIt concept]
- CASQ2 wt Allele [NCIt concept]
- COX6A2 wt Allele [NCIt concept]
- COX6C wt Allele [NCIt concept]
- COX7A2L wt Allele [NCIt concept]
- MT-CO1 wt Allele [NCIt concept]
- MYH6 wt Allele [NCIt concept]
- RYR2 wt Allele [NCIt concept]
- SLC8A1 wt Allele [NCIt concept]
- SLC9A1 wt Allele [NCIt concept]
- SLC9A6 wt Allele [NCIt concept]
- TNNI3 wt Allele [NCIt concept]
- TNNT2 wt Allele [NCIt concept]
- TPM1 wt Allele [NCIt concept]
- TPM2 wt Allele [NCIt concept]
- TPM3 wt Allele [NCIt concept]
- TPM4 wt Allele [NCIt concept]
- UQCRH wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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