Tropomyosin Alpha-1 Chain

Preferred Label : Tropomyosin Alpha-1 Chain;

NCIt synonyms : Sarcomeric Tropomyosin Kappa; Alpha-Tropomyosin; Tropomyosin, Skeletal Muscle Alpha; Tropomyosin-1; TPM1;

NCIt definition : Tropomyosin alpha-1 chain (284 aa, 33 kDa) is encoded by the human TPM1 gene. This protein plays a role in muscle contraction.;

NCIt note : There are at least 10 isoforms for the tropomyosin alpha-1 chain protein, which result from alternative splicing. Some of these isoforms are expressed in a cell-type specific manner. (UniProt);

Details

Origin ID

C113125;

UMLS CUI

C0384723;

Automatic exact mappings (from CISMeF team)
- Tropomyosin 1 [OMIM gene]
- alpha-Tropomyosin [MeSH concept]
- tropomyosin [MeSH Descriptor]
OMIM relation
- Tropomyosin 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TPM1 protein, human [MeSH Supplementary Concept]
- TPM1 protein, human [MeSH concept]
gene_encodes_gene_product
- Cytoskeletal Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
- TPM1 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Muscle Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
- Thin Filament [NCIt concept]
gene_product_has_biochemical_function
- Actin-Binding Protein [NCIt concept]
gene_product_is_element_in_pathway
- Cardiac Muscle Contraction Pathway [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
- Hypertrophic Cardiomyopathy Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Movement Process [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- Muscle Contraction [NCIt concept]
- Regulation of Cell Shape [NCIt concept]

Keyword's position in hierarchy(ies) :

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