Spliceosome Pathway

Preferred Label : Spliceosome Pathway;

NCIt related terms : Spliceosome;

Alternative definition : KEGG: After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.;

KEGG ID : hsa03040;

Details

Origin ID

C91451;

UMLS CUI

C2984264;

Automatic exact mappings (from CISMeF team)
- spliceosomal complex [GO term]
- spliceosomes [MeSH Descriptor]
- spliceosomes [MeSH concept]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Heat Shock 70 kDa Protein 1A/1B [NCIt concept]
- Heterogeneous Nuclear Ribonucleoprotein A1 [NCIt concept]
- Heterogeneous Nuclear Ribonucleoprotein A3 [NCIt concept]
- Heterogeneous Nuclear Ribonucleoprotein K [NCIt concept]
- Heterogeneous Nuclear Ribonucleoprotein M [NCIt concept]
- Poly(rC)-Binding Protein 1 [NCIt concept]
- Polyglutamine-Binding Protein 1 [NCIt concept]
- Pre-mRNA-Processing Factor 40 Homolog B [NCIt concept]
- Pre-mRNA-Splicing Factor ATP-Dependent RNA Helicase DHX15 [NCIt concept]
- Probable ATP-Dependent RNA Helicase DDX5 [NCIt concept]
- Putative Pre-mRNA-Splicing Factor ATP-Dependent RNA Helicase DHX16 [NCIt concept]
- RNA-Binding Protein 8A [NCIt concept]
- SNW Domain-Containing Protein 1 [NCIt concept]
- Serine/Arginine-Rich Splicing Factor 1 [NCIt concept]
- Serine/Arginine-Rich Splicing Factor 2 [NCIt concept]
- Serine/Arginine-Rich Splicing Factor 3 [NCIt concept]
- Small Nuclear Ribonucleoprotein F [NCIt concept]
- Small Nuclear Ribonucleoprotein Sm D3 [NCIt concept]
- Spliceosome RNA Helicase DDX39B [NCIt concept]
- Splicing Factor 3B Subunit 1 [NCIt concept]
- Splicing Factor 3B Subunit 3 [NCIt concept]
- Splicing Factor U2AF 35 kDa Subunit [NCIt concept]
- Splicing Factor U2AF 65 kDa Subunit [NCIt concept]
- U4/U6.U5 Tri-SnRNP-Associated Protein 1 [NCIt concept]
pathway_has_gene_element
- CRNKL1 wt Allele [NCIt concept]
- DDX39B wt Allele [NCIt concept]
- DDX5 wt Allele [NCIt concept]
- DHX15 wt Allele [NCIt concept]
- DHX16 wt Allele [NCIt concept]
- HNRNPA1 wt Allele [NCIt concept]
- HNRNPA3 wt Allele [NCIt concept]
- HNRNPK wt Allele [NCIt concept]
- HNRNPM wt Allele [NCIt concept]
- HSPA1A wt Allele [NCIt concept]
- HSPA1B wt Allele [NCIt concept]
- PCBP1 wt Allele [NCIt concept]
- PQBP1 wt Allele [NCIt concept]
- PRPF40B wt Allele [NCIt concept]
- RBM8A wt Allele [NCIt concept]
- SART1 wt Allele [NCIt concept]
- SF3B1 wt Allele [NCIt concept]
- SF3B3 wt Allele [NCIt concept]
- SNRPD3 wt Allele [NCIt concept]
- SNRPF wt Allele [NCIt concept]
- SNW1 wt Allele [NCIt concept]
- SRSF1 wt Allele [NCIt concept]
- SRSF2 wt Allele [NCIt concept]
- SRSF3 wt Allele [NCIt concept]
- U2AF1 wt Allele [NCIt concept]
- U2AF2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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