Substance-P Receptor

Preferred Label : Substance-P Receptor;

NCIt synonyms : TACR1; Neurokinin 1 Receptor; Substance P Receptor; TAC1R; NK-1 Receptor; NK1R; NKIR; Tachykinin 1 Receptor; SPR; Tachykinin Receptor-1; NK-1R; Tachykinin Receptor 1;

NCIt definition : Substance-P receptor (407 aa, 46 kDa) is encoded by the human TACR1 gene. This protein is involved in tachykinin-dependent G protein-coupled receptor signaling.;

NCIt note : Substance-P receptor affinity for tachykinins from highest to lowest is: substance P, substance K, neuromedin K. (UniProt);

Details

Origin ID

C41023;

UMLS CUI

C4281804;

Currated CISMeF NLP mapping
- receptors, Neurokinin-1 [MeSH concept]
- receptors, neurokinin-1 [MeSH Descriptor]
OMIM relation
- Tachykinin receptor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TACR1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Neural Peptide Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Fosaprepitant Dimeglumine [NCIt concept]
- Fosnetupitant/Palonosetron Hydrochloride [NCIt concept]
- Netupitant [NCIt concept]

Keyword's position in hierarchy(ies) :

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