" /> Fosaprepitant Dimeglumine - CISMeF





Preferred Label : Fosaprepitant Dimeglumine;

NCIt related terms : Emend for Injection;

NCIt definition : The dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis.;

Alternative definition : NCI-GLOSS: A drug used together with other drugs to prevent and control nausea and vomiting caused by cancer treatment. It is given in a vein. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist.;

UNII : D35FM8T64X;

InChIKey : VRQHBYGYXDWZDL-OOZCZQCLSA-N;

CAS number : 265121-04-8;

Drug name : Proemend;

Molecule name : L-785,298; MK-0517;

Chemical formula : C23H22F7N4O6P.2C7H17NO5;

ChEBI ID : CHEBI:64311;

Codes from synonyms : CDR0000648590; CDR0000648591;

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09/05/2025


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