Fosaprepitant - CISMeF

Preferred Label : Fosaprepitant;

NCIt definition : A water-soluble, N-phosphorylated prodrug of the substance P (SP; neurokinin 1 (NK1)) antagonist aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent selectively binds to and blocks the human substance P receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis.;

UNII : 6L8OF9XRDC;

InChIKey : BARDROPHSZEBKC-OITMNORJSA-N;

CAS number : 172673-20-0;

Chemical formula : C23H22F7N4O6P;

ChEBI ID : CHEBI:64321;

Codes from synonyms : 233;

Details

Origin ID

C72787;

UMLS CUI

C2349941;

Automatic exact mappings (from CISMeF team)
- Aprepitant [MeSH Descriptor]
Currated CISMeF NLP mapping
- Fosaprepitant [SMS substance]
- Fosaprepitant (substance) [SNOMED CT concept]
- fosaprepitant [MeSH Supplementary Concept]
- fosaprepitant [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Fosaprepitant (substance) [SNOMED CT concept]
- Product containing fosaprepitant (medicinal product) [SNOMED CT concept]
- fosaprepitant [MeSH Supplementary Concept]
- fosaprepitant [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Fosaprepitant Dimeglumine [NCIt concept]
is_free_acid_or_base_form_of
- Fosaprepitant Dimeglumine [NCIt concept]

Keyword's position in hierarchy(ies) :

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