" /> Netupitant - CISMeF





Preferred Label : Netupitant;

NCIt synonyms : 2-[3,5-bis(Trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide;

NCIt definition : A selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.;

UNII : 7732P08TIR;

InChIKey : WAXQNWCZJDTGBU-UHFFFAOYSA-N;

CAS number : 290297-26-6;

Molecule name : CID6451149; D05152; RO 67-3189/000;

Chemical formula : C30H32F6N4O;

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24/06/2025


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