Preferred Label : IL5 Signaling Pathway;
NCIt related terms : IL 5 Signaling Pathway;
Alternative definition : BIOCARTA: IL-5 is an inflammatory signaling molecule that primarily stimulates eosinophil
proliferation, maturation, and activation. Eosinophils are leukocytes involved in
inflammatory responses that defend against parasites and cause some aspects of asthma,
allergic reactions, and perhaps autoimmune disorders. The action of IL-5 begins with
an immune response in tissues, such as activation of macrophages and T cells that
secrete IL-1, IL-4, and IL-6. The immune response can lead to IL-5 secretion by T
cells, eosinophils, and mast cells. Secreted IL-5 stimulates production and maturation
of eosinophils in bone marrow that migrate to tissues in response to eotaxin and release
factors that damage tissues, causing some of the undesirable consequences of inflammation.
The receptor for IL-5 is a heterodimer of an alpha subunit that is required for IL-5
selective binding and a beta subunit that is also part of the IL-3 and GM-CSF receptors.
Binding of IL-5 to the IL-5 receptor at the cell surface activates JAK/STAT signaling
pathways that regulate transcription, proliferation, and differentiation. (This definition
may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_il5Pathway;
Origin ID : C39126;
UMLS CUI : C1512597;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
