L-Dopachrome Tautomerase

Preferred Label : L-Dopachrome Tautomerase;

NCIt synonyms : Tyrosinase-Related Protein 2; TYRP2; EC 5.3.3.12; TRP-2; DCT; TRP2; DT; L-Dopachrome Delta-Isomerase; Tyrosinase-Related Protein-2;

NCIt definition : L-dopachrome tautomerase (519 aa, 59 kDa) is encoded by the human DCT gene. This protein is involved in the biosynthesis of melanin.;

NCIt note : Peptides from L-dopachrome tautomerase are used in vaccine therapy for treatment of melanomas.;

Details

Origin ID

C2646;

UMLS CUI

C1455430;

OMIM relation
- Dopachrome tautomerase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DCT protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
endogenous_product_related_to
- Recombinant Tyrosinase-Related Protein-2 [NCIt concept]
gene_encodes_gene_product
- DCT Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_malfunction_associated_with_disease
- Melanoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Melanogenesis [NCIt concept]
is_target
- HLA-A*0201-restricted TRP2-gp100-EphA2-HER2 Multipeptide Vaccine [NCIt concept]
- Multi-glioblastoma-peptide-targeting Autologous Dendritic Cell Vaccine ICT-107 [NCIt concept]
- TRP-2: 180-188 Peptide [NCIt concept]
- TRP2 mRNA-electroporated Autologous Langerhans-type Dendritic Cell Vaccine [NCIt concept]

Keyword's position in hierarchy(ies) :

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