NCIt definition : Human MCPH1 wild-type allele is located in the vicinity of 8p23.1 and is approximately
237 kb in length. This allele, which encodes microcephalin protein, is involved in
both brain development and DNA damage checkpoints. Mutation of the gene is associated
with primary, autosomal-recessive microcephaly 1.;
NCIt note : There is a report of a chromosomal aberration involving the AGPAT5 gene and the MCPH1
gene, which is associated with breast cancer. (COSMIC);