Preferred Label : TRP2 mRNA-electroporated Autologous Langerhans-type Dendritic Cell Vaccine;
NCIt definition : A cancer cell vaccine composed of autologous human Langerhans-type dendritic cells
(also known as Langerhans cells or LCs) that are electroporated with mRNA encoding
full-length murine tyrosinase-related peptide 2 (TRP2), with potential antineoplastic
and immunomodulating activities. Upon vaccination, the TRP2 mRNA-electroporated autologous
Langerhans-type dendritic cell vaccine may stimulate the immune system to mount a
cytotoxic T-lymphocyte (CTL) response against TRP2-expressing tumor cells. TRP2, a
tautomerase involved in the synthesis of melanin, is only expressed in melanomas,
melanocytes, and the retina. The LCs are differentiated from CD34 positive hematopoietic
progenitor cells.;
NCI Metathesaurus CUI : CL432936;
Origin ID : C99114;
UMLS CUI : C3274537;
Semantic type(s)
- concept_is_in_subset
- has_target
