Preferred Label : Deubiquitinating Enzyme;
NCIt definition : Deubiquitinating Enzymes are hydrolases that catalyze cleavage of ubiquitinated substrates
with addition of H2O at the point of cleavage. Protein ubiquitination regulates the
half-lives of many proteins by targeting them for degradation. Ubiquitination and
deubiquitination enzymes participate in highly regulated protein degradation, chromatin
remodeling, heat shock, cell cycle progression, differentiation, antigen presentation,
apoptosis, signal transduction, transcriptional activation, biological clocks, receptor
down regulation, and endocytosis.;
Origin ID : C21557;
UMLS CUI : C1333282;
Automatic exact mappings (from CISMeF team)
- Biochemical function of gene products
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_has_structural_domain_or_motif
- gene_product_plays_role_in_biological_process
