Ubiquitin Thioesterase Otulin

Preferred Label : Ubiquitin Thioesterase Otulin;

NCIt synonyms : EC 3.4.19.12; OTU Domain-Containing Deubiquitinase With Linear Linkage Specificity; Ubiquitin Thioesterase Gumby; Deubiquitinating Enzyme Otulin; OTULIN;

NCIt definition : Ubiquitin thioesterase otulin (352 aa, 40 kDa) is encoded by the human OTULIN gene. This protein plays a role in the downregulation of both protein ubiquitination and inflammation.;

Details

Origin ID

C176456;

UMLS CUI

C5444436;

OMIM relation
- Otu deubiquitinase with linear linkage specificity [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- OTULIN Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Deubiquitinating Enzyme [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Deubiquitination [NCIt concept]
- Hydrolysis [NCIt concept]
- Negative Regulation of Inflammatory Response Process [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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