Lys-63-Specific Deubiquitinase BRCC36

Preferred Label : Lys-63-Specific Deubiquitinase BRCC36;

NCIt synonyms : BRCA1/BRCA2-Containing Complex Subunit 36; BRISC Complex Subunit BRCC36; EC 3.4.19.-; BRCA1-A Complex Subunit BRCC36; BRCA1/BRCA2-Containing Complex Subunit 3; BRCC3;

NCIt definition : Lys-63-specific deubiquitinase BRCC36 (316 aa, 36 kDa) is encoded by the human BRCC3 gene. This protein plays a role in DNA repair and the removal of ubiquitin from histones.;

NCIt note : Lys-63-specific deubiquitinase BRCC36 catalyzes the removal of ubiquitin from lysine 63 in histones H2A and H2AX at DNA lesion sites. (UniProt);

Details

Origin ID

C124111;

UMLS CUI

C1872069;

Automatic exact mappings (from CISMeF team)
- BRCA1/BRCA2-containing complex subunit 3 [ORDO Gene]
- BRCA1/BRCA2-containing complex subunit 3 [HGNC gene]
- Brca1/brca2-containing complex, subunit 3 [OMIM gene]
OMIM relation
- Brca1/brca2-containing complex, subunit 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BRCC3 protein, human [MeSH Supplementary Concept]
- BRCC3 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- BRCC3 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
- Deubiquitinating Enzyme [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
- Protein Complex Subunit [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Deubiquitination [NCIt concept]
- Double Strand Break Repair [NCIt concept]
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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