T-Cell Receptor Activation

Preferred Label : T-Cell Receptor Activation;

NCIt synonyms : TCR Interaction; TCR Activation; T-Cell Receptor Interaction;

NCIt definition : Any process in which a specific pair of interactions is observed between a T cell and an antigen-presenting cell, where the interactions include those between the T cell receptor and the major histocompatibility complex and those between CD28 and B7 family members. This process is involved in anergy and specification of the immune response to a particular antigen.;

NCIt note : TCR Activation during T cell development and proliferation involves binding to specific antigen by Ig-like heterodimeric transmembrane surface alpha/beta (antigen/MHC) or gamma/delta (antigen) glycoprotein receptors non-covalently associated with CD3 complex on T lymphocytes. Antigen-bound TCRs activate MAPKs and JNK1 through CD3 antigens, adaptor protein LAT, and tyrosine kinases LCK and ZAP70.;

Details

Origin ID

C19060;

UMLS CUI

C1515144;

Automatic exact mappings (from CISMeF team)
- obsolete T cell receptor activity [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
biological_process_has_initiator_chemical_or_drug
- Signaling Molecule [NCIt concept]
biological_process_has_result_biological_process
- T-Cell Activation [NCIt concept]
biological_process_involves_gene_product
- HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain [NCIt concept]
- Interleukin-23 Subunit Alpha [NCIt concept]
- Signal Transducer and Activator of Transcription 5B [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Delta Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Epsilon Chain [NCIt concept]
- Tyrosine-Protein Kinase CSK [NCIt concept]
biological_process_is_part_of_process
- Intercellular Communication Process [NCIt concept]
biological_process_results_from_biological_process
- Antigen Presentation [NCIt concept]
is_physiologic_effect_of_chemical_or_drug
- ALVAC-B7-CEA [NCIt concept]
- ALVAC-CEA (VCP248) [NCIt concept]
- ALVAC-hB7.1 [NCIt concept]
- B7 Transfected Melanoma Cell Vaccine [NCIt concept]
process_involves_gene
- CD3D Gene [NCIt concept]
- CD3D wt Allele [NCIt concept]
- CD3E Gene [NCIt concept]
- CD3E wt Allele [NCIt concept]
- CSK Gene [NCIt concept]
- CSK wt Allele [NCIt concept]
- HLA-DQB1 Gene [NCIt concept]
- HLA-DQB1 wt Allele [NCIt concept]
- STAT5B Gene [NCIt concept]
- STAT5B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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