Methionine Aminopeptidase 2

Preferred Label : Methionine Aminopeptidase 2;

NCIt synonyms : Eukaryotic Initiation Factor 2-Associated Protein, 67-kD; Peptidase M; MAP 2; p67; EIF-2-Associated p67 Homolog; Initiation Factor 2 Associated 67 kDa Glycoprotein; MetAP 2; Testicular Tissue Protein Li 17; EC 3.4.11.18; p67eIF2; Methionyl Aminopeptidase 2; METAP2; Initiation Factor 2-Associated 67 kDa Glycoprotein;

NCIt definition : Methionine aminopeptidase 2 (478 aa, 53 kDa) is encoded by the human METAP2 gene. This protein plays a role in both the steric hindrance of phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1) and the removal of the amino-terminal methionine from nascent proteins.;

Details

Origin ID

C143021;

UMLS CUI

C1433609;

Automatic exact mappings (from CISMeF team)
- Cd33 antigen [OMIM gene]
- Methionine aminopeptidase 2 [OMIM gene]
- Methionyl aminopeptidase (substance) [SNOMED CT concept]
- methionine aminopeptidase 2 [MeSH Supplementary Concept]
- methionine aminopeptidase 2 [MeSH concept]
- methionyl aminopeptidase 1 [HGNC gene]
- methionyl aminopeptidase 2 [HGNC gene]
- methionyl aminopeptidases [MeSH Descriptor]
OMIM relation
- Methionine aminopeptidase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- METAP2 protein, human [MeSH Supplementary Concept]
- METAP2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- METAP2 Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Metal Binding Site [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]
- Translational Regulation [NCIt concept]
is_target
- Evexomostat [NCIt concept]
- Extended-Release MetAP2 Inhibitor APL-1501 [NCIt concept]
- Fumagillin-Derived Polymer Conjugate XMT-1107 [NCIt concept]
- MetAP2 Inhibitor APL-1202 [NCIt concept]
- Methionine Aminopeptidase 2 Inhibitor M8891 [NCIt concept]

Keyword's position in hierarchy(ies) :

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