Preferred Label : Fumagillin-Derived Polymer Conjugate XMT-1107;
NCIt definition : A polymeric prodrug consisting of the fumagillol-derived small molecule XMT-1191 tethered
to the hydrophilic, biodegradable70 kDa polymer poly[1-hydroxymethylethylene hydroxymethylformal]
(PHF) with potential antiangiogenic and antineoplastic activities. Upon administration,
fumagillin-derived polymer conjugate XMT-1107 releases XMT-1191, which may inhibit
angiogenesis through the irreversible inhibition of the methionine aminopeptidase
2 (METAP2); although the exact mechanism of action has yet to be fully elucidated,
this agent appears to induce cell cycle arrest in endothelial cells, inhibiting their
proliferation and migration. Compared to an unconjugated fumagillin analog, XMT-1107
exhibits improved solubility and an extended half life due to its PHF backbone. METAP2,
a member of the methionyl aminopeptidase family, binds two cobalt or manganese ions
and protects the alpha subunit of eukaryotic initiation factor 2 (EIF2) from inhibitory
phosphorylation by removing the amino-terminal methionine residue from nascent protein;
this aminopeptidase may be overexpressed in a variety of tumor cell types.;
Molecule name : XMT-1107;
NCI Metathesaurus CUI : CL413581;
Origin ID : C88321;
UMLS CUI : C2981838;
Semantic type(s)
- concept_is_in_subset
- has_target
