Preferred Label : MetAP2 Inhibitor APL-1202;
NCIt synonyms : Methionine Aminopeptidase Type II Inhibitor APL-1202;
NCIt definition : An orally available inhibitor of methionine aminopeptidase II type (MetAP2) with potential
antiangiogenic and antineoplastic activities. Upon administration, APL-1202 binds
to and reversibly inhibits MetAP2, thereby preventing MetAP2-mediated signal transduction
pathways. This may suppress endothelial cell growth and inhibit tumor angiogenesis,
resulting in tumor cell death. MetAP2, a member of the dimetallohydrolase family,
is upregulated in certain tumor cell types and plays a key role in angiogenesis, proliferation
and survival.;
Molecule name : APL 1202; APL-1202;
NCI Metathesaurus CUI : CL970968;
Origin ID : C162480;
UMLS CUI : C5206587;
Semantic type(s)
- concept_is_in_subset
- has_target
