Preferred Label : Methionine Aminopeptidase 2 Inhibitor M8891;
NCIt synonyms : MetAP2 Inhibitor M8891;
NCIt definition : A proprietary orally available inhibitor of methionine aminopeptidase 2 (MetAP2),
which cleaves the amino-terminal methionine residue from nascent proteins, with potential
antiangiogenic and antineoplastic activities. Upon administration, MetAP2 inhibitor
M8891 inhibits MetAP2 aminopeptidase activity and impairs protein synthesis, which
may lead to a decrease in endothelial cell proliferation. Decreased proliferation
of endothelial cells results in reductions of both angiogenesis and the growth and
spread of solid tumors that are dependent on new blood vessel formation. MetAP2, a
metallopeptidase, is involved in promoting protein synthesis and endothelial cell
proliferation.;
Molecule name : M8891;
NCI Metathesaurus CUI : CL540704;
Origin ID : C142831;
UMLS CUI : C4684848;
Semantic type(s)
- concept_is_in_subset
- has_target
