Preferred Label : Evexomostat;
NCIt synonyms : Methionine aminopeptidase type II Inhibitor SDX-7320; MetAP2 Inhibitor SDX-7320;
NCIt definition : A synthetic copolymer-drug conjugate of a fumagillin-derived methionine aminopeptidase
2 (MetAP2) inhibitor conjugated to the bio-compatible polymer poly(N-(hydroxypropyl)methacrylamide)
(HPMA), with potential antineoplastic activity. Upon administration of SDX-7320, the
active moiety SDX7539 is released inside the tumor cells. SDX7539 binds to and inhibits
MetAP2, which prevents MetAP2-mediated signal transduction pathways and results in
tumor cell death. MetAP2, a member of the dimetallohydrolase family upregulated in
certain tumor cell types, plays a key role in angiogenesis, proliferation and survival.
Polymer conjugation reduces systemic drug exposure and increases this agent's efficacy
as compared to non-polymer conjugates.;
UNII : Z7116W3IFA;
CAS number : 2416263-67-5;
Molecule name : SDX-7320;
NCI Metathesaurus CUI : CL507924;
Origin ID : C128030;
UMLS CUI : C5667152;
Semantic type(s)
- concept_is_in_subset
- has_target
