Preferred Label : Extended-Release MetAP2 Inhibitor APL-1501;
NCIt synonyms : ER APL1501; Ethionine Aminopeptidase Type II Inhibitor APL-1501; ER APL 1501; ER APL-1501;
NCIt definition : An extended-release (ER) formulation of APL-1501, an orally available inhibitor of
methionine aminopeptidase II type (MetAP2), with potential antiangiogenic and antineoplastic
activities. Upon administration, ER MetAP2 inhibitor APL-1501 is released from the
formulation over an extended period of time and targets, binds to and reversibly inhibits
MetAP2, thereby preventing MetAP2-mediated signal transduction pathways. This may
suppress endothelial cell growth and inhibit tumor angiogenesis, resulting in tumor
cell death. MetAP2, a member of the dimetallohydrolase family, is upregulated in certain
tumor cell types and plays a key role in angiogenesis, proliferation and survival.
Compared to APL-1202, APL-1501 has improved pharmacokinetic (PK) characteristics.
The ER formulation allows for controlled drug release, enhanced drug plasma exposure
time and reduced medication intake frequency.;
Molecule name : APL-1301;
NCI Metathesaurus CUI : CL1661908;
Origin ID : C179267;
UMLS CUI : C5555567;
Semantic type(s)
- concept_is_in_subset
- has_target
