ribosomal protein S6 kinases, 70-kDa

Preferred Label : ribosomal protein S6 kinases, 70-kDa;

MeSH definition : A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.;

MeSH synonym : p70 s6 kinase; p70s6k; s6 kinase, p70; ribosomal protein S6 kinases, 70 kDa;

CISMeF synonym : EC 2.7.1.37;

Registry Number MeSH : EC 2.7.11.1;

Is substance : O;

UNII : EC 2.7.11.1;

Details

Origin ID

D038762;

UMLS CUI

C1136240;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 [NCIt concept]
- Aurora Kinase C [NCIt concept]
- Cell Division Cycle 7-Related Protein Kinase [NCIt concept]
- Cyclin-Dependent Kinase 10 [NCIt concept]
- Cyclin-Dependent Kinase 2 [NCIt concept]
- Cyclin-Dependent Kinase 3 [NCIt concept]
- Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2 [NCIt concept]
- MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2 [NCIt concept]
- Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1 Beta [NCIt concept]
- Nik-Related Protein Kinase [NCIt concept]
- RPS6KB1 wt Allele [NCIt concept]
- Ribosomal Protein S6 Kinase Beta-1 [NCIt concept]
- Serine/Threonine-Protein Kinase 33 [NCIt concept]
- Serine/Threonine-Protein Kinase Nek10 [NCIt concept]
- Transcription Initiation Factor TFIID Subunit 1 [NCIt concept]
Indexing information
- LY2584702 [MeSH Supplementary Concept]
- PF-4708671 [MeSH Supplementary Concept]
Record concept(s)
- ribosomal protein S6 kinases, 70-kDa [MeSH concept]
Related MeSH Supplementary Concept(s)
- Rsks-1 protein, C elegans [MeSH Supplementary Concept]
- ribosomal protein S6 kinase, 70kD, polypeptide 1 [MeSH Supplementary Concept]
- ribosomal protein S6 kinase, 70kD, polypeptide 2 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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