Cyclin-Dependent Kinase 10

Preferred Label : Cyclin-Dependent Kinase 10;

NCIt synonyms : PISSLRE Protein; Cyclin-Dependent Kinase-10; EC 2.7.1.11; Serine/Threonine-Protein Kinase PISSLRE; CDK10 Protein; CDK10; Cell Division Protein Kinase 10; EC 2.7.11.22;

NCIt definition : Cyclin-dependent kinase 10 (360 aa, 41 kDa) is encoded by the human CDK10 gene. This protein plays a role in cell cycle regulation and protein phosphorylation.;

NCIt note : This protein kinase is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is involved in promoting DNA synthesis and cell cycle progression. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene exist. Its N-terminal domain interacts with cyclins and C-terminal domain interacts with CSK1. (LocusLink, OMIM);

Details

Origin ID

C25841;

UMLS CUI

C1568280;

OMIM relation
- Cyclin-dependent kinase 10 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CDK10 protein, human [MeSH concept]
- CDK10 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CDK10 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin-Dependent Kinase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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