Cyclin-Dependent Kinase 3

Preferred Label : Cyclin-Dependent Kinase 3;

NCIt synonyms : Cyclin-Dependent Kinase-3; EC 2.7.1.11; Cyclin-Dependent Protein Kinase 3; CDK3; EC 2.7.11.22; Cell Division Protein Kinase 3;

NCIt definition : Cyclin-dependent kinase 3 (305 aa, 35 kDa) is encoded by the human CDK3 gene. This protein may play a role in cell cycle regulation.;

NCIt note : Cyclin-Dependent Kinase 3, encoded by the CDK3 gene, belongs to the SER/THR family of protein kinases. CDK3 can phosphorylate histone H1. CDK3 is involved in the control of the cell cycle. CDK3 participates in the G1-S transition at least primarily by binding to E2F-1, E2F-2, or E2F-3 through DP-1 and by enhancing their transcriptional activities. CDK3 also interacts with cyclin E and cyclin A and Ik3-1/Cables is a novel substrate for CDK3-mediated phosphorylation by CDK3/cyclin E and CDK3/cyclin A. (LocusLink, PubMed);

Details

Origin ID

C25865;

UMLS CUI

C1447440;

Currated CISMeF NLP mapping
- Cyclin-Dependent kinase 3 [MeSH Descriptor]
- Cyclin-Dependent kinase 3 [MeSH concept]
OMIM relation
- Cyclin-dependent kinase 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CDK3 protein, human [MeSH concept]
- CDK3 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- CDK3 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin-Dependent Kinase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- G1 to S Transition Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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